Statement on Code and Agent Technology

Third-Party & Open-Source Libraries Used

Paramus no longer utilizes code from other chemistry agent system repositories, as it is either incompatible with modern agent design or has diverged significantly.

In the program itself, under the „Licenses“ menu item, all libraries, their authors, and the respective license models are listed. As this list changes frequently, please refer to the program directly for the most up-to-date information.

Legacy Code

In legacy version 1.x of the PARAMUS Open Cheminformatics Agent (until 03/2025), components of the following agent systems were included:

• ChemCrow, from Bran et al., 2023 [arXiv:2304.05376]. MIT License.
• CACTUS (Chemistry Agent Connecting Tool-Usage to Science), described in McNaughton et al., 2024 [arXiv:2405.00972]. BSD 2-Clause „Simplified“ License.
• ChemAgent: Tooling or Not Tooling? The Impact of Tools on Language Agents for Chemistry Problem Solving, Yu et al., 2024 [arXiv:2411.07228]. MIT License.
• MDCrow: Automating Molecular Dynamics Workflows with Large Language Models, Campbell, Q., Cox, S., Medina, J., Watterson, B., & White, A. D. (2025). arXiv:2502.09565 [cs.AI]. MIT License.

We do utilize widely recognized open-source libraries – such as Dash – to power specific functionalities, uphold best practices, and enhance the overall reliability of our platform.