Paramus Chemistry OS
A integrated, AI centered platform for computational chemistry, models, laboratory automation, and semantic data management.
Paramus Chemistry OS brings four integrated modules onto a single local machine:
- AI copilot for chemistry (INTENT),
- (classic) AI model and HPC server (BRAIN)
- Big Data and Semantic knowledge graph (WORLD),
- Robotic orchestration platform (OPERATE).
All layers (excl. Operate) are hosting Apps, this may be legacy programs, AI models, classic programs (like ELN, CDB) or data cartridges.
Four Modules
Paramus Chemistry OS consists of four integrated modules that work together as a unified platform. Each module can also be downloaded and licensed independently.
INTENT
AI-Powered Chemistry Copilot
Large language models are excellent at explaining science, but they do not do science on their own. INTENT grounds LLMs in real calculations and models, turning plausible text into validated results. It connects OpenAI, Claude, and local LLMs to the full Paramus computation stack.
Key Features
- Multi-LLM support: OpenAI, Claude, local models
- Grounded in computation, not just language
- Direct access to BRAIN models and WORLD context
- Chemistry-aware prompt routing
WORLD
Semantic Information Server
A LLM-driven physical objects representation store based on a knowledge graph. WORLD learns and updates itself from information sources and text, autonomously modeling complex relationships between people, substances, equipment, and locations to provide semantic context to LLMs.
Key Features
- RDF knowledge graph with SPARQL queries
- One-click dataset installation
- Autonomous entity extraction from text and email
- JSON-RPC API with JWT authentication
BRAIN
AI Models and High Performance Server
Plugin architecture for AI chemistry models (Gen3 deep learning and Gen4 LLMs), including AIMNet2, MatterSim, and MatterGen. Provides a model router for intelligent request routing and load balancing, plus HPC application hosting for LAMMPS, ORCA, and 40+ scientific computing tools.
Key Features
- AI models: AIMNet2, MatterSim, MatterGen, ORB
- HPC: LAMMPS, ORCA, GROMACS, NWChem, CP2K
- Model router with load balancing
- CUDA GPU acceleration support
OPERATE
Robotic Platform Server
Robotic orchestration platform for modern chemistry research. Integrates robotic liquid handlers, analytical instruments, and data acquisition systems through a unified JSON-RPC API with ISA-88 batch control standards for full traceability and regulatory compliance.
Key Features
- ISA-88 batch control with S88-light recipes
- 123 API methods for full programmatic control
- Opentrons OT-2 and MQTT sensor support
- Automated batch records and audit trails
How They Work Together
- INTENT receives a research question and routes it to the right computation backend.
- BRAIN executes AI models (AIMNet2, MatterSim) and HPC applications (ORCA, LAMMPS) and returns results.
- WORLD stores entities, relationships, and datasets in a knowledge graph, providing semantic context.
- OPERATE drives robotic instruments and captures experimental data with ISA-88 batch records.
System Requirements
Depends on the module. You can run all modules on one older laptop, min 16GB and 256 GB SSD. But expect no wonders, i.e. route scouting or CFD visualization will not start (automatic system checker to preserve performance).
- OS: Windows 10/11 (64-bit), Linux
- RAM: 16 GB minimum, 32 GB recommended (BRAIN)
- Storage: INTENT: 10 GB free disk space, all apps installed: 750GB
- GPU (optional): CUDA capable
- Network: Internet for initial download and updates
- LLM API: OpenAI or Claude key (for INTENT)
- Deployment: On-premise, air-gapped capable