Copilot is free for:
- Academic, educational, and non-profit use. All modules, apps and agents included.
- Contributors (also commercial) for three years following their last significant commit, regardless of current commercial affiliation. Maintain your repo to retain access!
- Startups on request (fair use). Basically bundling (with your ecosystem or agents) is possible, lets talk about it.
Legal restrictions apply. Click here for Paramus Academic Access.
Copilot
Includes Desktop, Connectors, Apps, and AI Agents
Desktop
The User Interface of Copilot
- Chat dialogs
- Save/Restore/Resume Chats
- Configuration for agents
- Context Designer
- MCP Client
An extra subscription is needed for AI models like ChatGPT or Claude (~$10/mo)
Cheminformatics
(CINF)
Free computational tools for molecules and reactions
- RDKit
- Chemfiles
Data Systems
(DATA)
Workflow from ELN, LIMS, SDMS, LES
- Read experiments
- Read out reactor timeseries
- Find LIMS calibrations
SYSTEMS: (Ask for custom implementations)
- ChemInf-EDU (ELN and LIMS)
Organic Chemistry
(ORGN)
Devise synthetic routes for chemical compounds
- Proposes pathways for molecule synthesis, evaluates feasibility
- Aligns synthesis plans with LLM’s strategic objectives
ASKCOS (limited guest account); LICENCE FOR IBM RXN NEEDED
Literature
(TEXT)
Aggregate and read existing chemical research, also online DBs
- Searches Google and pubchem
- Updates Copilot with latest research, requests summaries on topics
some API-KEYS NEEDED
Computational & Physical Chemistry
(COMP, PHYS)
Quantum chemical calculations
- Runs molecular dynamics, quantum chemistry calculations, predicts kinetics and thermodynamics, calculate theoretical spectra
- PSI4, openMM, PySCF
Statistics and Data Science
(DSML)
Random Forest, and SVM
DoE:
- General and 2-level Full-Factorial
- 2-level Fractional
- Plackett-Burman
- Generalized Subset
Response-Surface and Randomized:
- Box-Behnken
- Central-Composite
- Latin-Hypercube
Coder
(CODE)
Can do calculations and simple Document reading, Export
- Calculator (Python)
- Build-in Jupyter Notebook
Material Science & Inorganic Chemistry
(INOR)
Materials discovery
- Property calculations
- Structure analysis
- Electronic property determination
- Solid-state thermodynamic stability assessment
Materials Project API Key needed
Autoring
(TEXT)
EXPERIMENTAL
Content Levels:
- Simple Summary
- Slide Deck (Draft)
- Conference Abstract
Chemical Engineering
(CENG)
Unit operations, Scale up
Polymer Chemistry
(POLY)
Getting Started
- All PARAMUS software is delivered as local application (Mac or PC). Data and chats are stored on your file system.
- You find the installer downloads here.
- The software is available through a subscription. Upon registration, a lifetime license file is issued to activate your copy, granting access to the basic features.
- So your work remains accessible and readable forever – even without an active subscription! However, access to agents is restricted to users with an active support plan.
Chemist
This new actor is build on PARAMUS Copilot and has the ability to act in the background without supervision. It is intended for time-consuming advanced reasoning (like ChatGPT Research). It has implemented asynchronous agent access ( = parallel).
Researcher, as independent actor
- Offline processing – working on a local LLM (use Gemma-3 (Google), or DeepSeek-R1 for single CPU)
- Submit / Receive thoughts (part of chats)
- On top of the PARAMUS Copilot (5 seats/installations included, but dedicated to the Chemist)
- Multi – job in parallel
- Simple communication interface: just through mail or Teams chat (Google or Microsft)
Why a local LLM? Two reasons:
- Token consumption is enormous. The chemist runs 24/7 and operates across vast knowledge domains.
- Data privacy and protection. A novel molecule can generate significant revenue. The metric of data distance – i.e., how far patent-relevant information is stored physically – represents a critical competitive factor.